Brown Norway rat model of pneumonic plague
Posted by: admin | March 03, 2009 | 0 Comments
Pneumonic plague (Yersinia pestis) is most commonly studied in mice and monkeys1, 2, 3. Recently, a team of scientists from the University of Missouri and the University of Chicago used the Brown Norway rat to investigate the plague’s mechanism of action because of the similar clinical and histological effects the bubonic plague has on humans and this species of rat. In this study, the Brown Norway rat is not only introduced and described as a model but is also utilized for evaluation of pneumonic plague vaccines.
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2 Williamson E, Eley S, Griffin K, Green M, Russell P, Leary S, Oyston P, Easterbrook T, Reddin K, Robinson A, Titball R: A new improved sub-unit vaccine for plague: the basis for protection. FEMS Immunol Med Microbiol 1995, 12:223-230.
3 Williamson E, Flick-Smith H, LeButt C, Rowland C, Jones S, Waters E, Gwyther R, Miller J, Packer P, Irving M: Human immune response to a plague vaccine comprising recombinant F1 and V antigens. Infect Immun 2005, 73:3598-3608.
4 Sebbane F, Gardner D, Long D, Gowen B, Hinnebusch B: Kinetics of disease progression and host response in a rat model of bubonic plague. Am J Pathol 2005, 166:1427-1439.